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We study the aging eye with a focus on
retinal blood vessels, neurons and immune cells.
Disease of the aging eye affect hundreds of millions of individuals worldwide. The retina, a thin membrane of central nervous tissue at the back of the eye, integrates light and transforms it to sight. Our laboratory studies vascular diseases of the retina such as diabetic retinopathy and age-related macular degeneration with a focus on neuroinflammation, vascular permeability and microvascular remodeling. We aim to bring, and have brought, our fundamental discoveries to clinic.
Cellular senescence has often been associated with aging or cell cycle arrest, yet it is a convergent response to several types of cellular damage. We study triggers of cellular senescence, how senescence contributes to disease or health and how we can therapeutically eliminate senescence cells.
Immune memory has classically been attributed to the adaptive immune system through T cells and B cells. In recent years, it has become apparent that cells of the innate immune system such as macrophages and microglia can themselves retain memory. We study innate immune memory and how it contributes to neuroinflammation.
Blood vessels in the central nervous system (CNS) play critical roles in supplying oxygen, nutrients, immune cells and more to ensure tissue homeostasis. We study how the blood retinal barrier is maintained in health and how it brakes down in diseases such as diabetic retinopathy.
Our lab is located at the
Pavillion Claudine D’Amours,
Maisonneuve Rosemont Research Center
Montreal, Quebec, Canada
Sapieha Lab 