PubMed link to all lab papers

( Denotes key papers)



  • The effects of anti-VEGF and kinin B1receptor blockade on retinal inflammation in laser-induced choroidal neovascularization. Hachana S, Fontaine O, Sapieha P, Lesk M, Couture R, Vaucher E. Br J Pharmacol. 2019 Dec 27.
  • The protein tyrosine phosphatase PTPRJ/DEP-1 contributes to the regulation of the Notch-signaling pathway and sprouting angiogenesis. Fournier P, Viallard C, Dejda A, Sapieha P, Larrivée B, Royal I. Angiogenesis. 2019 Oct 9.
  • RELi protocol: Optimization for protein extraction from white, brown and beige adipose tissues. Diaz Marin R, Crespo-Garcia S, Wilson AM, Sapieha P. MethodsX. 2019 Apr 182019.04.010


  • in vivo laser-mediated retinal ganglion cell optoporation using KV1.1 conjugated gold nanoparticles. Wilson AM, Mazzaferri J, Bergeron E, Patskovsky S, Marcoux-Valiquette P, Costantino S, Sapieha P*, Meunier M*. Nano Lett. 2018 Oct 4. doi: 10.1021/acs.nanolett . *co-corresponding
  • Postmitotic Cellular Senescence: Beyond Growth Arrest.  Sapieha P* & Mallette F*, Trends in Cell Biology 2018 Aug;28(8):595-607  *Co-corresponding.
  • ★Macrophage-resident Neuropilin-1 safeguards against obesity and metabolic syndrome. A Wilson, Z Shao, V Grenier, G Mawambo, J-F Daudelin, A Dejda, F Pilon, N Popovic, S Boulet, C Parinot, M Oubaha, N Labrecque, V de Guire, M Laplante, G Lettre, F Sennlaub, J-S Joyal, M Meunier, P Sapieha. Science Immunology,  Mar 16;3(21) .
  • Nogo-A inhibits vascular regeneration in ischemic retinopathy. Sandrine Joly, Agnieszka Dejda, Lea Rodriguez, Przemyslaw Sapieha*, Vincent Pernet*. Glia 2018 Jul 27  *co-corresponding.
  • BMP9/Alk1 signaling prevents hyperglycemia-induced vascular permeability Naoufal Akla, Claire Viallard, Cindy Pao, Natalija popovic, Przemyslaw Sapieha, Bruno Larrivée. ATVB, 2018 Jun 7. pii: ATVBAHA.118.310733.
  • A machine learning approach for automated assessment of retinal vasculature in the oxygen induced retinopathy model. Mazzaferri J, Larrivée B, Cakir B, Sapieha P, Costantino S. Scientific Reports. 2018 Mar 2;8(1):3916.
  • Effect of human very low-density lipoproteins on cardiotrophin-like cytokine factor 1 (CLCF1) activity. S Pasquin, S Chehboun, A Dejda, Y Meliani, V Savin, G Warner, R Bosse, A Tormo, G Mayer, M Sharma, P Sapieha, C Martel and J-F Gauchat, Scientific Reports 2018 Mar 5;8(1):3990.


  • miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD). SanGiovanni JP, SanGiovanni PM, Sapieha P, De Guire V. Clin Chem Lab Med. 2017 Mar 27.
  • Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation. B Calippe, S Augustin, F Beguier, H Charles-Messance, L Poupel, J-B Conart, S J. Hu, S Lavalette, A Fauvet, J Rayes, O Levy, W Raoul, C Fitting, T Denefle, M Pickering, C Harris, S Jorieux, PM Sullivan, J-A Sahel, P Karoyan, P Sapieha, X Guillonneau, EL Gautier, F Sennlaub Immunity, 2017 Feb 21: 46(2):261-272.


  • Lymphocytic Microparticles Modulate Angiogenic Properties of Macrophages in Laser-induced Choroidal Neovascularization. Tahiri H, Omri S, Yang C, Duhamel F, Samarani S, Ahmad A, Vezina M, Bussières M, Vaucher E, Sapieha P, Hickson G, Hammamji K, Lapointe R, Rodier F, Tremblay S, Royal I, Cailhier JF, Chemtob S, Hardy P. Sci Rep. 2016 Nov 22;6:37391.
  • Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization. E Andriessen , A Wilson , G Mawambo , K Miloudi , F Sennlaub, P Sapieha. EMBO Mol Med. 2016 Dec 1;8(12):1366-1379.
  • VEGF Requires the Receptor NRP-1 To Inhibit Lipopolysaccharide-Dependent Dendritic Cell Maturation. Oussa NA, Dahmani A, Gomis M, Richaud M, Andreev E, Navab-Daneshmand AR, Taillefer J, Carli C, Boulet S, Sabbagh L, Labrecque N, Sapieha P, Delisle JS. J Immunol. 2016 Nov 15;197(10):3927-3935.
  •  Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy. Oubaha M, Miloudi K, Dejda A, Wilson AM, Rezende, FA Mallette FA, Sapieha P. Science Translational Medicine. 2016 Oct 26;8(362):362ra144. In editorial highlights.
  • p75NTR and Its Ligand ProNGF Activate Paracrine Mechanisms Etiological to the Vascular, Inflammatory, and Neurodegenerative Pathologies of Diabetic Retinopathy. P Barcelona, N Sitaras, A Galan, G Esquiva, S Jmaeff, Y Jian, M Sarunic,N Cuenca, P Sapieha,* and H. Uri Saragovi * The Journal of Neuroscience. 2016 Aug 24;36(34):8826-41 * co-corresponding in (Highlights of JNeurosci).
  • Neurovascular Crosstalk in Diabetic Retinopathy: Pathophysiological Roles and Therapeutic Moran EP, Wang Z, Chen J, Sapieha P, Smith LE, Ma JX. Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H738-49.
  • Truncated Netrin-1 Contributes to Pathological Vascular Permeability in Diabetic Retinopathy Miloudi K, Binet F, Wilson AM, Dejda A, Oubaha M, Cerani A, Rezende, FA, Bourgeault S, Kennedy TE, Sapieha P. J Clin Invest. 2016 Aug 1;126(8):3006-22. In Highlights of JCI.
  • Neuropilin-1 expressing microglia are associated with nascent vasculature yet dispensable for retinal angiogenesis. A Dejda, G Mawambo, K Miloudi, J-F Daudelin, N Labrecque, Sennlaub F, Sapieha P. Invest Ophthalmol Vis Sci. 2016 Apr;57(4):1530-6. doi: 10.1167/iovs.15-18598.
  • MicroRNA signatures in vitreous humour and plasma of patients with exudative AMD Menard C, Rezende F, Miloudi K, Tetreault N, SanGiovanni JP, DeGuire V, Sapieha P. Oncotarget. 2016 Apr 12;7(15):19171-84. doi: 10.18632/oncotarget.8280.
  • Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Joyal JS, Sun Y, Gantner ML, Shao Z, Evans LP, Saba N, Fredrick T, Burnim S, Kim JS, Patel G, Juan AM, Hurst CG, Hatton CJ, Cui Z, Pierce KA, Bherer P, Aguilar E, Powner MB, Vevis K, Boisvert M, Fu Z, Levy E, Fruttiger M, Packard A, Rezende FA, Maranda B, Sapieha P, Chen J, Friedlander M, Clish CB, Smith LE. Nat Med. 2016 Apr;22(4):439-45.


  • Cell-specific optoporation with near-infrared ultrafast laser and functionalized gold nanoparticles. Bergeron E, Boutopoulos C, Martel R, Torres A, Rodriguez C, Niskanen J, Lebrun JJ, Winnik FM, Sapieha P, Meunier M. Nanoscale. 2015 Nov 14;7(42):17836-47.
  • SYK is a target of lymphocyte-derived microparticles in the induction of apoptosis of human retinoblastoma cells. Qiu Q, Yang C, Xiong W, Tahiri H, Payeur M, Superstein R, Carret AS, Hamel P, Ellezam B, Martin B, Vezina M, Sapieha P, Liu G, Hardy P. 2015 Dec;20(12):1613-22.
  • Retinal neurons curb inflammation and enhance revascularization in ischemic retinopathies via proteinase-activated receptor-2. Sitaras N, Rivera JC, Noueihed B, Bien-Aimé M, Zaniolo K, Omri S, Hamel D, Zhu T, Hardy P, Sapieha P, Joyal JS, Chemtob S. Am J Pathol. 2015 Feb;185(2):581-95.
  • Netrin-1-DCC signalling systems in age-related macular degeneration. *SanGiovanni JP, Chen J, Chew E, Sapieha P*, Lee P*. PLOSOne 2015 May 7;10(5):e0125548. * EQUAL CONTRUBTION


  • Neuropilin-1 mediates myeloid cell chemoattraction and influences retinal neuroimmune crosstalk A Dejda, G Mawambo, A Cerani, K Miloudi, Z Shao, J-F Daudelin, S Boulet, M Oubaha, F Beaudoin, N Akla, S Henriques, C Menard, A Stahl, J-S Delisle, FA Rezende, N Labrecque, P Sapieha, J Clin Invest. 2014 Nov;124(11):4807-22.
  • Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Joyal JS, Nim S, Zhu T, Sitaras N, Rivera JC, Shao Z, Sapieha P, Hamel D, Sanchez M, Zaniolo K, St-Louis M, Ouellette J, Montoya-Zavala M, Zabeida A, Picard E, Hardy P, Bhosle V, Varma DR, Gobeil F Jr, Beauséjour C, Boileau C, Klein W, Hollenberg M, Ribeiro-da-Silva A, Andelfinger G, Chemtob S. Nat Med. 2014 Oct;20(10):1165-73.
  • Omega-3 Supplementation Combined With Anti-Vascular Endothelial Growth Factor Lowers Vitreal Levels of Vascular Endothelial Growth Factor in Wet Age-Related Macular Degeneration Rezende FA, Lapalme E, Qian CX, Smith LE, SanGiovanni JP, Sapieha P. Am J Ophthalmol. 2014 Aug 1. (14)00472-3
  • Evaluation of the vitreous microbial contamination rate in office-based three-port microincision vitrectomy surgery using Retrector technology. Rezende FA, Qian CX, Sapieha P. BMC Ophthalmol. 2014 May 1;14(1):58.
  • Assessment of Vascular Regeneration in the CNS Using the Mouse Retina K Miloudi, A Dejda, F Binet, E Lapalme, A Cerani, P Sapieha. Vis. Exp. e51351, doi:10.3791/51351 (2014).
  • Anti-proliferative and anti-tumour effects of lymphocyte-derived microparticles are neither species- nor tumour-type specific. Yang C, Xiong W, Qiu Q, Tahiri H, Superstein R, Carret AS, Sapieha P, Hardy P. J Extracell Vesicles. 2014 May 9;3. doi: 10.3402/jev.v3.23034. eCollection 2014.
  • Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization–brief report. Shao Z, Fu Z, Stahl A, Joyal JS, Hatton C, Juan A, Hurst C, Evans L, Cui Z, Pei D, Gong Y, Xu D, Tian K, Bogardus H, Edin ML, Lih F, Sapieha P, Chen J, Panigrahy D, Hellstrom A, Zeldin DC, Smith LE. Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):581-6.



  • Omega-3 polyunsaturated fatty acids preserve retinal function in type 2 diabetic mice,  P Sapieha, J Chen, A Stahl, MR Seaward, TL Favazza, AM Juan, CJ Hatton, J-S Joyal, NM Krah, RJ Dennison, J Tang, TS Kern, JD Akula and LEH Smith. Nutr Diabetes. 2012 Jul 23;2:e36.
  • SOCS3 is an endogenous inhibitor of pathologic angiogenesis.Stahl A, Joyal JS, Chen J, Sapieha P, Juan AM, Hatton CJ, Pei DT, Hurst CG, Seaward MR, Krah NM, Dennison RJ, Greene ER, Boscolo E, Panigrahy D, Smith LE 2012 Oct 4;120(14):2925-9. doi: 10.1182/blood-2012-04-422527.
  • Retinal expression of wnt-pathway mediated genes in low-density lipoprotein receptor-related protein 5 (lrp5) knockout mice.Chen J, Stahl A, Krah NM, Seaward MR, Joyal JS, Juan AM, Hatton CJ, Aderman CM, Dennison RJ, Willett KL, Sapieha P, Smith LE. PLoS One. 2012;7(1):e30203


  • Wnt signaling mediates pathological vascular growth in proliferative retinopathy. Chen, A. Stahl, N.M. Krah, M.R. Seaward, R.J. Dennison, P. Sapieha, J. Hua, C. Hatton, A.M. Juan, C.M. Aderman, K.L. Willett, K.I. Guerin, A. Mammoto, M. Campbell, L.E.H. Smith, Circulation, 2011 Oct 25;124(17):1871-81
  • The ghrelin/GSHR-1 axis is a central mediator of retinal vasoproliferation. Zaniolo K*, Sapieha P*,(equal contribution) Zhuo S, Stahl A, Smith LE, Ong H, Chemtob S. Invest Ophthalmol Vis Sci. Jul 23;52(8):5376-86
  • Central choroidal atrophy is a key mediator of retinal dysfunction in retinopathy of prematurity. Shao, A. Dorfman, S. Seshadri, E. Kermorvant-Duchemin, F. Sennlaub, A. Polosa, P. Lachapelle, P. Hardy, J. Mancini, P. Sapieha, S. Chemtob. Invest Ophthalmol Vis Sci. 2011 Aug 5;52(9):6238-48.
  • Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. JS Joyal, N Sitaras, F Binet, K Zaniolo, A Stahl, Z Shao, A Polosa, M Djavari, D Kunik, D Hamel, JCHonoré, JC Rivera, A Zabeida, D Varma, G Hickson, J Mancini, M Klagsbrun, S Costantino, C Beauséjour, P Lachapelle, L Smith, S Chemtob and P Sapieha. Blood 2011;117(22):6024-35. Cover article with editorial.
  • 5-Lipoxygenase Mediates Anti-angiogenic Effects of ω-3 PUFAs on Proliferative Retinopathy. Sapieha P, Stahl A, Seaward M, Chen J, Krah N, Denission R, Connor KM, Gronert K & Willett K, Smith LE. Science Translational Medicine. 2011 Feb 9;3(69):69ra12. Cover article and editorial in New England Journal of Medicine (May 19th, 2011).
  • Resveratrol Inhibits Pathological Retinal Neovascularization in Vldlr-/- Mice.Jing Hua, Karen I. Guerin, Jing Chen, Shaday Michan, Andreas Stahl, Nathan M. Krah, Molly R. Seaward, Roberta J. Dennison, Aimee M. Juan, Colman J. Hatton , Przemyslaw Sapieha, David Sinclair, Lois E. H. Smith. Invest Ophthalmol Vis Sci. 2011 Apr 25;52(5):2809-16.
  • Cortactin activation by tissue factor/FVIIa and PAR2 promotes porcine cerebral microvascular endothelial cell migration. Tang zhu, Joseph Mancini, Przemyslaw Sapieha, Zhu T, Mancini JA, Sapieha P, Yang C, Joyal JS, Honoré JC, Leduc M, Zaniolo K, Hardy P, Shao Z, Fan L, Hou X, Rivard GE, Chemtob S. Am J Physiol Regul Integr Comp Physiol. 2011 Mar;300(3):R577-85.


  • CD36 plays an important role in the clearance of oxLDL and associated age-dependent sub-retinal deposits Picard E, Houssier M, Bujold K, Sapieha P, Lubell W, Dorfman A, Racine J, Hardy P, Febbraio M, Lachapelle P, Ong H, Sennlaub F, Chemtob.. Aging, 2010 Dec; 2(12):981-9
  • “PPARγ mediates the anti-angiogenic effect of ω3-PUFAs in proliferative retinopathy” Stahl A*, Sapieha P* (equal contribution), Connor KM, Chen J, Guérin K, Krah N, Denission R, Gronert K & Willett K, Smith LE. Circulation Research. * equal contribution. 2010 Aug 20; (4):495-500
  • Postnatal weight gain modifies severity and functional outcome of oxygen-induced proliferative retinopathy. Stahl A, Chen J, Sapieha P, Seaward MR, Krah NM, Dennison RJ, Favazza T, Bucher F, Löfqvist C, Ong H, Hellström A, Chemtob S, Akula JD, Smith LE. Am J Pathol. 2010 Dec;177(6):2715-23. American Journal of Pathology. 2010 Nov 5. Cover Article.


  • Swift-NV; automated quantification of neovscularization. Stahl A, Connor K, Sapieha P, Chen J, Guérin K, Krah N, Denission R, Gronert K & Willett K, Smith LE. Angiogenesis, 2009;12(3):297-301.
  • Quantification of Oxygen-induced Retinopathy in the Mouse – A Model of Vessel Loss, Vessel Regrowth, and Pathological Angiogenesis. Connor K, Stahl A, Chen J, Guérin K, Krah N, Denission R, Gronert K & Willett K, Sapieha P, Smith LE. Nat Protoc. 2009;4(11):1565-73. Epub 2009 Oct 8.
  • VRQ397 (CRAVKY): a novel non-competitive V2 receptor antagonist.  Rihakova L, Quiniou C, Hamdan F, Kaul R, Brault S, Hou X, Lahaie I, Sapieha P, Hamel D, Zhuo S, Gobeil F Jr, Joyal JS, Nedev H, Heveker N, Saragovi H, Guillon G, Bouvier M, Lubell WD, Chemtob S. Am J Physiol Regul Integr Comp Physiol. 2009 Oct;297(4):R1009-18.
  • Excitotoxic death of retinal neurons in vivo occurs via a non-cell autonomous mechanism. Lebrun-Julien F, Duplan L, Pernet V, Osswald I, Sapieha P, Bourgeois P, Dickson K, Bowie D, Barker PA, Di Polo A. The Journal of Neuroscience. 2009 Apr 29;29(17):5536-45.



  • Redox-dependent lysophosphatidic acid-induced endothelial cell death. Brault S, Gobeil F, Fortier A, Honoré JC, Joyal JS, Sapieha P,  Kooli A, Martin E, Ribeiro-da-Silva A, Peri K, Lachapelle P, Varma D, Chemtob S. Am J Physiol Regul Integr Comp Physiol. 2007 Mar; 292  1174-83.


  • Hyperoxic exposure leads to nitrative stress and ensuing microvascular degeneration, and diminished brain mass and function in the immature subject. Sirinyan M, Sennlaub M, Dorfman A, Sapieha P, Gobeil Jr F, Hardy P, Lachapelle P, Chemtob S. Stroke. 2006 Nov; 37: 2807-15
  • Extracellular Signal-Regulated Kinases 1/2 Mediate Retinal Ganglion Cell Axon Regeneration Induced by Fibroblast-Growth Factor-2. Sapieha P, Hauswirth W, Di Polo A. The Journal of Neuroscience Res., 2006, 1;83 :985-95.


  • Receptor Protein Tyrosine Phosphatase Sigma Inhibits Axon Regrowth in the Adult Injured CNS.Sapieha P, Duplan L, Uetani N,  Joly S, Tremblay M, Kennedy TE,  Di Polo A. Molecular Cell Neuroscience, 2005 28: 625-35.



  • TrkB Gene Transfer Protects Retinal Ganglion Cells from Axotomy-Induced Death In Vivo Cheng L, Sapieha P, Kittlerova P, Hauwswirth W, and Di Polo A.. The Journal of Neuroscience. 2002 22: 3977-3986.


  • Down-regulation of Human DNA-(Cytosine-5) Methyltransferase Induces Cell Cycle Regulators p16ink4A and p21WAF/Cip1 by Distinct Mechanisms. Fournel M, Sapieha P, Beaulieu N, Besterman J, MacLeod AR. Journal of Biological Chemistry. 1999 274: 24250-24256.



  • Postmitotic Cellular Senescence: Beyond Growth Arrest. Sapieha P* & Mallette F* (Co-corresponding). Trends in Cell Biology. 2018
  • On phagocytes and macular degeneration. Guillonneau X, Eandi CM, Paques M, Sahel JA, Sapieha P, Sennlaub F. Prog Retin Eye Res. 2017
  • Neurons and guidance cues in retinal vascular diseases. Wilson A, Sapieha P. Oncotarget. 2016 Mar 1;7(9):9618-9.
  • ER Stress and Angiogenesis. Binet F Sapieha P. Cell Metabolism. 2015 Aug 12. pii: S1550-4131(15)00339-
  • Circulating miRNAs as sensitive and specific biomarkers for the diagnosis and monitoring of human diseases: Promises and chal  De Guire V, Robitaille R, Tétreault N, Guérin R, Ménard C, Bambace N, Sapieha P. Clin Biochem. 2013 Jul;46(10-11):846-60.
  • Eyeing Central Neurons in Vascular Growth and Reparative Angiogenesis. Sapieha P. Blood, June 15, 2012.
  • Lipid metabolites in the pathogenesis and treatment of neovascular eye disease. Stahl A, Krohne TU, Sapieha P, Chen J, Hellstrom A, Chew E, Holz FG, Smith LE. Br J Ophthalmol. 2011 Nov;95(11):1496-501. Br J Ophthalmol. 2011 Mar 18.
  • Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life. Sapieha P, Joyal J-S, Rivera JC, Kermorvant-Duchemin E, Sennlaub F, Hardy P, Lachapelle P, Chemtob S, J Clin Invest . 2010 Sep 1;120(9):3022-32
  • Proliferative retinopathies: Angiogenesis that Blinds. Sapieha P, Hamel D, Shao Z, Rivera JC, Zaniolo K and Chemtob S. Int J Biochem Cell Biol. 2010 Jan;42(1):5-12.
  • The Mouse Retina as a model of Angiogenesis Stahl A, Connor K, Sapieha P, Chen J, Guérin K, Krah N, Denission R, Gronert K & Willett K, Smith LE. Invest Ophthalmol Vis Sci. 2010 Jun;51(6):2813-26.
  • Understanding ischemic retinopathies: emerging concepts from oxygen-induced retinopathy. Kermorvant E, Sapieha P, Sirinyan M, Beauchamp M, Checchin D, Hardy P, Lachapelle P, Sennlaub F, Chemtob S. Documenta Ophthalmol, Doc Ophthalmol. 2010 Feb;120(1):51-60.
  • Supply and demand: the influence of energy metabolism on angiogenesis. Sapieha P, Zaniolo K, Hamel D, Joyal JS, Chemtob S. Med Science. 2009 Apr; 25(4):346-8.
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